James Fletcher, Ph.D.

Dr. James Fletcher

Associate Professor, Organic Chemistry

(402) 280-2273
jamesfletcher@creighton.edu
B.S. Chm., University Nebraska (1996)
PhD University of Pennsylvania (2001)

Each student project in the Fletcher lab involves the preparation of organic or organometallic small molecules for a variety of applications. Students who work with the Fletcher group will learn common techniques synthetic chemists use to prepare, isolate, purify and characterize small molecules. Some projects additionally involve running assays to measure biological activity or sensor activity, and the optoelectronic characterization of new compounds. Currently active projects include:

  • Development and optimization of new tandem click reactions
  • Development of new fluorescent chemosensors and assaying for activity towards ionic and organic analytes of biological relevance
  • Design and synthesis of biologically active small molecules and testing for antimicrobial and enzyme inhibitory properties
  • Preparation and characterization of organometallic complexes for applications in bio-imaging and drug delivery
Selected Publications:
  1. Fletcher, J.T.; Reilly, J.E. “Fast dye salts provide fast access to azidoarene synthons in multi-step one-pot click transformations” Tetrahedron Lett. 2011, 52, 5512-5515.
  2. Fletcher, J.T.; Keeney, M.E.; Walz, S.E. “1-Allyl and 1-Benzyl-3-methyl-1,2,3-triazolium Salts via Tandem Click Transformations” Synthesis 2010, 19, 3339-3345.
  3. Fletcher, J.T.; Boriraj, G. “Benzodiazepine Synthesis and Rapid Toxicity Assay” Journal of Chemical Education 2010, 87, 631-633.
  4. Fletcher, J.T.; Bumgarner, B.J.; Engels, N.D.; Skoglund, D.A. “Multidentate 1,2,3-Triazole-Containing Chelators from Tandem Deprotection/Click Reactions of (Trimethylsilyl)alkynes and Comparison of Their Ruthenium(II) Complexes” Organometallics, 2008, 27, 5430-5433.
  5. Fletcher, J.T.; Walz, S.E.; Keeney, M.E. “Monosubstituted 1,2,3-triazoles from two-step one-pot deprotection/click additions of trimethylsilylacetylene” Tetrahedron Lett. 2008, 49, 7030-7032.
  6. Fletcher, J.T.; Finlay, J.A.; Callow, M.E.; Callow, J.A.; Ghadiri, M.R. “A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant Staphylococcus aureus (MRSA) and E-coli and the biofouling algae Ulva linza and Navicula perminuta Chem. Eur. J.2007, 13, 4008-4013.
  7. Fletcher, J.T.; Therien, M.J.“Extreme Electronic Modulation of the Cofacial Porphyrin Structural Motif” J. Am. Chem. Soc. 2002, 124(16), 4298-4311.
  8. Fletcher, J.T.; Therien, M.J. “Strongly Coupled Porphyrin Arrays Featuring Both ¹-Cofacial and Linear-¹-Conjugative Interactions” Inorg. Chem.2002, 41(2), 331-341.
  9. Fletcher, J.T.; Therien, M.J.“Transition-Metal-Mediated [2 + 2 + 2] Cycloaddition Reactions with Ethyne-Containing Porphyrin Templates: New Routes to Cofacial Porphyrin Structures and Facially-Functionalized (Porphinato)metal Species”
  10. J. Am. Chem. Soc. 2000, 122(49), 12393-12394.
  11. Moore, K.T.; Fletcher, J.T.; Therien, M.J. “Synthesis, NMR and EPR Spectroscopy, Electrochemical Properties, and Structural Studies of [5,10,15,20-Tetrakis(perfluoroalkyl)porphinato]iron(II) and -iron(III) Complexes” J. Am. Chem. Soc. 1999, 121(22), 5196-5209.